课题组主页：https://www.x-mol.com/groups/HXH_NJTech

个人简历

2016至今   南京工业大学，教授

2012-2016   新加坡南洋理工大学，化学与生物化学系， 博士后
2007-2012   新加坡南洋理工大学，化学与生物化学系， 博士
2004-2007   南开大学，元素有机化学研究所，硕士
2000-2004   中国农业大学，应用化学系，国家理科基地班，学士

研究方向 

廉价过渡金属催化的碳氢键官能化反应和氧化偶联反应；以结构复杂的药物分子和天然产物合成为导向的新方法学研究。

学术成绩

集中于廉价过渡金属催化新型有机化学反应的研究，包括反应机理和在药物分子和天然产物合成中的应用。在国际期刊Journal of the American Chemical Society, Angewandte Chemie International Edition，ACS Catalysis, Organic Letters等发表研究论文二十余篇，曾获南京市第十二届自然科学优秀学术论文奖。2017年入选江苏省“双创博士”项目，2018年获南京留学人员科技创新项目择优资助。主持并完成国家和江苏省自然科学基金青年项目各一项。 

代表性论文

Publications @ NJTech

25. Ming-Qing Tian, Zhen-Yao Shen, Xuefei Zhao, Patrick J. Walsh*, Xu-Hong Hu*. Iron-catalyzed tertiary alkylation of terminal alkynes with 1,3-diestersvia a functionalized alkyl radical.

Angew. Chem. Int. Ed. 2021, 60, 9706-9711.

24. Rui-Hua Liu#, Qi-Chao Shan#, Ya Gao, Teck-Peng Loh*, Xu-Hong Hu*. Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides.

Chin. Chem. Lett. 2021, 32, 1411-1414.

23. Song Li#, Qi-Chao Shan#, Lu-Min Hu, Xue-Qing Ma, Xu-Hong Hu*. Merging alkenyl C-H activation with the ring-opening of 1,2-oxazetidines: ruthenium-catalyzed aminomethylation of enamides.

Chem. Commun. 2020, 56, 7969-7972.

22. Rui-Hua Liu, Zhen-Yao Shen, Cong Wang, Teck-Peng Loh, Xu-Hong Hu*. Selective dehydrogenative acylation of enamides with aldehydes leading to valuable βketoenamides.

Org. Lett. 2020, 22, 944-949.

(highlighted by Organic Chemistry Portal)

21. Pengfei Shi, Song Li, Lu-Min Hu, Cong Wang, Teck-Peng Loh*, Xu-Hong Hu*. The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: easy entry to pyrimidin-4-ones.

Chem. Commun. 2019, 55, 11115-11118.

20. Zhen-Yao Shen#, Jun-Kee Cheng#, Cong Wang, Chao Yuan, Teck-Peng Loh*, Xu-Hong Hu*. (# equal contribution) Iron-catalyzed carbamoylation of enamides with formamides as a direct approach to N-acyl enamine amides.

ACS Catal. 2019, 9, 8128-8135.

(Highlighted by X-Mol)

19. Rui-Hua Liu, Qi-Chao Shan, Xu-Hong Hu*, Teck-Peng Loh*. Site-selective C(sp3)-H amination of thioamide with anthranils under Cp*CoIII catalysis.

Chem. Commun. 2019, 55, 5519-5522.

18. Ming-Qing Tian, Cong Wang, Xu-Hong Hu*, Teck-Peng Loh*. Divergent C-H oxidative radical functionalization of olefins to install tertiary alkyl motifs enabled by copper catalysis.

Org. Lett. 2019, 21, 1607-1611.

(Highlighted by Synfacts 2019, 15, 524)

17. Song Li, Pengfei Shi, Rui-Hua Liu, Xu-Hong Hu*, Teck-Peng Loh*. Cobalt-catalyzed N-O and C-C bond cleavage in 1,2-oxazetidines: solvent-controlled C-H aminomethylation and hydroxymethylation of heteroarenes.

Org. Lett. 2019, 21, 1602-1606.

16. Cong Wang, Rui-Hua Liu, Ming-Qing Tian, Xu-Hong Hu*, Teck-Peng Loh*. Regioselective copper-catalyzed oxidative coupling of α-alkylated styrenes with tertiary alkyl radicals.

Org. Lett. 2018, 20, 4032-4035.

15. Jun-Kee Cheng#, Liang Shen#, Liu-Hai Wu, Xu-Hong Hu*, Teck-Peng Loh*. (#equal contribution) Iron-catalyzed peroxidation-carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)-H functionalization.

Chem. Commun. 2017, 53, 12830-12833.

Publications before independent career

14. Xu-Hong Hu, Xiao-Fei Yang, Teck-Peng Loh*. Chelation-assisted rhodium-catalyzed direct amidation with amidobenziodoxolones: C(sp2)-H, C(sp3)-H and late-stage functionalizations. ACS Catal. 2016, 6, 5930-5934.

13. Xu-Hong Hu#, Xiao-Fei Yang#, Teck-Peng Loh*. (#equal contribution) Selective alkenylation and hydroalkenylation of enol phosphates through direct C-H functionalization. Angew. Chem., Int. Ed. 2015, 54, 15535-15539.

12. Xu-Hong Hu#, Jian Zhang#, Xiao-Fei Yang, Yun-He Xu*, Teck-Peng Loh*. (#equal contribution) Stereo- and chemoselective cross-coupling between two electron-deficient acrylates: an efficient route to (Z,E)-muconate derivatives. J. Am. Chem. Soc. 2015, 137, 3169-3172. (封面文章和亮点介绍)

11. Xu-Hong Hu, Feng Liu, Teck-Peng Loh*. Stereoelectronic verses steric tuning in the Prins cyclization reaction: synthesis of 2,6-trans pyranyl motifs. Org. Lett. 2009, 11, 1741-1743.

10. Xiao-Fei Yang, Xu-Hong Hu, Teck-Peng Loh*. Expedient synthesis of functionalized pyrroloquinolinones by Rh-catalyzed annulation of N-carbamoyl indolines with alkynes through a directed C-H functionalization/C-N cleavage sequence. Org. Lett. 2015, 17, 1481-1484.

9. Xiao-Fei Yang, Xu-Hong Hu, Chao Feng, Teck-Peng Loh*. Rhodium(III)-catalyzed C7-position C-H  alkenylation and alkynylation of indolines. Chem. Commum. 2015, 51, 2532-2535.

8. Ming-Xin Zhang, Xu-Hong Hu, Yun-He Xu*, Teck-Peng Loh*. Selective dealkylation of alkyl ether. Asian J. Org. Chem. 2015, 4, 1047-1049.

7. Han Xu, Xu-Hong Hu, Xiao-Mao Zou, You-Quan Zhu, Bin Liu, Fan-Zhong Hu, Hua-Zheng Yang*. Synthesis and herbicidal activity of 5-heterocycloxy-3-substituted-1-(3-trifluoromethyl)phenyl-1H-pyrazole. Chem. Res. Chin. Univ. 2012, 28, 824-827.

6. Hai-Qing Luo, Xu-Hong Hu, Teck-Peng Loh*. Highly stereocontrolled synthesis of fluorinated 2,6-trans dihydropyrans via Prins cyclization. Tetrahedron Lett. 2010, 51, 1041-1043.

5. Han Xu, Xu-Hong Hu, Bin Liu, You-Quan Zhu, Xiao-Mao Zou, Fan-Zhong Hu, Hua-Zheng Yang*. Synthesis and herbicidal activity of novel 6-methyl-4-(3-trifluoromethylphenyl)pyridazin-3(2H)-one. Chin. J. Org. Chem. 2010, 30, 1876-1883.

4. Han Xu, Xu-Hong Hu, You-Quan Zhu, Xiao-Mao Zou, Bin Liu, Fan-Zhong Hu, Hua-Zheng Yang*. Synthesis and herbicidal activities of novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives. Sci. China Chem. 2010, 53, 157-166.

3. You-Quan Zhu, Xu-Hong Hu, Han Xu, Yong Wang, Xiao-Mao Zou, Hua-Zheng Yang*. Synthesis and QSAR study of novel 8-(3-(trifluoromethyl)phenyl)-6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-ones. Arkivoc 2008, 12, 30-41.

2. Han Xu, Xu-Hong Hu, Xiao-Mao Zou, Bin Liu, You-Quan Zhu, Yong Wang, Fang-Zhong Hu, Hua-Zheng Yang*. Synthesis and herbicidal activities of novel 3-N-substituted amino-6-methyl-4-(3-trifluoromethylphenyl) pyridazine derivatives. J. Agric. Food Chem. 2008, 56, 6567-6572.

1. Han Xu, Xiao-Mao Zou, You-Quan Zhu, Bin Liu, Han-Lin Tao, Xu-Hong Hu, Hai-Bin Song, Fang-Zhong Hu, Yong Wang, Hua-Zheng Yang*, Synthesis and herbicidal activity of novel α,α,α-trifluoro-m-tolyl pyridazinone derivatives. Pest Manag. Sci. 2006, 62, 522-530.

胡绪红 教授

Email:ias_xhhu@njtech.edu.cn