个人简历

2016年至今   南京工业大学，先进化学制造研究院，教授

2013–2016   美国加州大学伯克利分校，博士后

2008–2013   美国纽约大学，博士

2004–2008   南京大学，学士

研究方向

研究工作围绕生物分子的修饰、分析与应用展开，包括了：

（1）靶向分子探针与药物

（2）新型生物正交反应

（3）蛋白运输系统

学术成绩

在生物正交反应、多肽分子开关、细菌探针、蛋白传送等领域完成了一系列的工作。共发表SCI论文32篇，其中包括以第一作者、通讯作者在Nat. Mater.，Nat. Commun.，Angew. Chem. Int. Ed.，Sci. Transl. Med.等国际一流期刊发表论文17篇。主持国家自然科学基金青年基金、江苏省自然科学基金青年基金各一项，2018年入选江苏省“双创博士”。兼任Biomedicine & Pharmacotherapy执行编辑（Executive Editor）。

代表性论文

1. Xia, Y.; Chen, Y.; Chen, J.; Han, X.; Wang, X.*; Li, D.* Gestational exposure to a fluorotelomer alcohol causes behavioral abnormalities by disrupting the blood–brain barrier in offspring. Environ. Chem. Lett. 2024, DOI: 10.1007/s10311-024-01707-5.

2. Li, Y.; Zeng, P.; Lou, Q.; Su, X.; Li, W.; Wang, X.* Prediction of 19F NMR Chemical Shifts for Organic Compounds with ORCA. J. Magn. Reson. 2024, 358, 107611.

3. Zhong, Y.; Xu, L.; Yang, C.; Xu, L.; Wang, G.; Guo, Y.; Cheng, S.; Tian, X.; Wang, C.; Xie, R.; Wang, X.*; Ding, L.*; Ju, H. Site-selected in situ polymerization for living cell surface engineering. Nat. Commun. 2023, 14, 7285.

4. Xia, Y.; Hao, L.; Li, Y.; Li, Y.; Chen, J.; Li, L.; Han, X.; Liu, Y.*; Wang, X.*; Li, D.* Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice. Ecotoxicol. Environ. Saf. 2023, 250, 114497.

5. Wang, J.; Tan, Y.; Dai, Y.; Hu, K.; Tan, X.; Jiang, S.; Li, G.; Zhang, X.; Kang, L.; Wang, X.*; Xu, B.* Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury. Int. J. Nanomedicine 2023, 18, 5495.

6. Wang, G.; Li, Q.; Guo, Y.; Chen, L.; Yao, Y.; Zhong, Y.; Sun, J.; Yan, X.; Wang, H.; Wang, X.*; Ding, L.*; Ju, H. Interception Proximity Labeling for Interrogating Cell Efflux Microenvironment. Anal. Chem. 2023, 95, 17798.

7. Tian, H.; Wang, Y.; Dai, Y.; Mao, A.; Zhou, W.; Cao, X.; Deng, H.; Lu, H.; Ding, L.;* Shen, H.;* Wang, X.*, A Cephalosporin-Tripodalamine Conjugate Inhibits Metallo-b-Lactamase with High Efficacy and Low Toxicity. Antimicrob. Agents Chemother. 2022, 2022, 66, e00352.

8. Wang, B.; Li, X.; Wang, Y.; Mao, X.; Wang, X.*, Post-translational site-specific protein azidolation with an azido pyridoxal derivative. Chem. Commun. 2022, 58, 7408

9. Xu, Y.; Li, W.; Zhou, X.; Gao, Y.; Ding, L.; Xu, L.; Mao, X.; Zhou, A.*; Wang, X.*; Ning, X.* Integrative Strategy for Investigating the Interactions between STING and Small-Molecule Ligands. Langmuir 2022, 38, 14185.

10. Mao, X.; Li, W.; Zhu, S.; Zou, J.; Tian, H.; Duan, Y.; Wang, Y.; Fei, J.; Wang, X.*, Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications. Chem. Commun. 2020, 56, 7601

11. Li, W.;^† Zou, J.;^† Zhu, S.; Mao, X.; Tian, H.; Wang, X.*, Fluorodibenzocyclooctynes: A Trackable Click Reagent with Enhanced Reactivity. Chem. Eur. J. 2019, 25, 10328.

12. Wang, X.; Borges, C. A.; Ning, X.; Rafi, M.; Zhang, J.; Park, B.; Takemiya, K.; Lo Sterzo, C.; Taylor, W. R.; Riley, L.; Murthy, N.*, A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjugate Chem. 2018, 29, 1729.

13. Lee, K.;^† Rafi, M.;^† Wang, X.;^† Aran, K.; Feng, X.; Sterzo, C. L.; Tang, R.; Lingampalli, N.; Kim, H.; Murthy, N.*, In vivo delivery of transcription factors with multifunctional oligonucleotides. Nat. Mater., 2015, 14, 701. (†equally contributed)

14. Wang, X.; Murthy, N.*, Bacterial Imaging Comes of Age. Sci. Transl. Med., 2014, 6, 259fs243.

15. Wang, X.; Bergenfeld, I.; Arora, P. S.*; Canary, J. W.*, Reversible Redox Reconfiguration of Secondary Structures in a Designed Peptide. Angew. Chem. Int. Ed. 2012, 51, 12099.

16.Wang, X.; Canary, J. W.*, Rapid Catalyst-Free Hydrazone Ligation: Protein-Pyridoxal Phosphoramides. Bioconjugate Chem. 2012, 23, 2329.

王晓剑 教授

Email:ias_xjwang@njtech.edu.cn